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Case Reports
. 1979 Feb;66(2):120-3.
doi: 10.1002/bjs.1800660212.

A reappraisal of the value of carcinoembryonic antigen in the management of patients with various neoplasms

M J Cooper, C R Mackie, D B Skinner, A R Moossa
Case Reports

A reappraisal of the value of carcinoembryonic antigen in the management of patients with various neoplasms

M J Cooper et al. Br J Surg. 1979 Feb.

Abstract

Eight hundred and eight patients with histologically proved malignant disease had carcinoembryonic antigen (CEA) estimations performed at the time of tissue diagnosis. An elevated level was found in 384 of 518 patients with gastrointestinal neoplasms (74 per cent) and in 162 of 290 patients with other neoplasms (56 per cent). No correlation was found between CEA elevations and tumour differentiation. There was a good correlation between tumour staging and CEA levels for patients with colorectal cancer; the more advanced the tumour, the higher the CEA. Several illustrative cases are presented and the role of CEA assay in the diagnosis and management of neoplasia is discussed. CEA assay is a poor screening test for neoplastic disease, but serial CEA monitoring is valuable in the detection of residual or recurrent cancer.

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References

    1. Abelev G J (1974) α-Fetoprotein as a marker of embyrospecific differentiation in normal and tumor tissues. Transplant. Rev. 20, 3–37. - PubMed
    1. Astler V B and Coller F A (1954) The prognostic significance of direct extension of carcinoma of the colon and rectum. Ann. Surg. 139, 846–852. - PMC - PubMed
    1. Bullen A W, Losowsky M S, Carter S et al. (1977) Diagnostic usefulness of plasma carcinoembryonic antigen levels in acute and chronic liver disease. Gastroenterology 73, 673–678. - PubMed
    1. Concannon J P, Dalbow M H and Frick J C (1973) Carcinoembryonic antigen plasma levels in untreated cancer patients and patients with metastatic disease. Radiology 108, 191–193. - PubMed
    1. Concannon J P, Dalbow M H, Liebler G A et al. (1974) The carcinoembryonic antigen assay in bronchogenic carcinoma. Cancer 34, 184–192. - PubMed

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