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. 1974 Apr;26(4):713-23.

Transplantable immunoglobulin-secreting tumours in rats. IV. Sixty-three IgE-secreting immunocytoma tumours

H Bazin, P Querinjean, A Beckers, J F Heremans, F Dessy

Transplantable immunoglobulin-secreting tumours in rats. IV. Sixty-three IgE-secreting immunocytoma tumours

H Bazin et al. Immunology. 1974 Apr.

Abstract

The inbred LOU/Wsl rat strain presents a high incidence of spontaneous ileocoecal immunocytoma which secrete monoclonal immunoglobulins. These tumours are transplantable in histocompatible animals and their secreting properties are maintained over many passages.

A screening of monoclonal immunoglobulins secreted by 250 such tumours revealed sixty-three proteins which shared class-specific determinants, physicochemical features and biological properties different from those of rat IgM, IgA, IgG1, IgG2a, IgG2b and IgG2c classes, and characteristic of proteins of the IgE class.

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