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Comparative Study
. 1974 Jun;27(6):457-62.
doi: 10.1136/jcp.27.6.457.

Assay of rifampicin in serum

J M Dickinson, V R Aber, B W Allen, G A Ellard, D A Mitchison
Comparative Study

Assay of rifampicin in serum

J M Dickinson et al. J Clin Pathol. 1974 Jun.

Abstract

Two methods for the assay of rifampicin in serum are described. The first is a conventional plate diffusion method, measuring concentrations down to 0.02 mug/ml, and the second a chemical extraction followed by measurement of the inhibition of uptake of (14)C-uridine by Staphylococcus aureus, which estimates in the range of 0.02 to 0.001 mug/ml. The methods were used to measure serum concentrations in man following doses of about 1050 mg and 75 mg rifampicin.

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References

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