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Clinical Trial
. 1974 Aug;49(8):636-40.
doi: 10.1136/adc.49.8.636.

Therapy in hereditary angioneurotic oedema

C M Gwynn
Clinical Trial

Therapy in hereditary angioneurotic oedema

C M Gwynn. Arch Dis Child. 1974 Aug.

Abstract

Two branches of a family suffering from hereditary angioneurotic oedema underwent trials of therapy of ε-amino caproic-acid (EACA) to ascertain the optimum dosage required to alleviate symptoms without giving rise to unpleasant side effects.

It was found that children under 11 years tolerated 3 g/day and patients over 11 years 6 g/day without side effects, but with incomplete control of symptoms in some of the patients. However, if the dose was doubled for a period of less than 4 days during times of expected and experienced trauma, better control was achieved and unpleasant muscle cramps were not experienced. These doses, though effective, were much smaller than those used in previous studies.

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References

    1. Pediatrics. 1966 Jun;37(6):1017-27 - PubMed
    1. Immunochemistry. 1965 Sep;2(3):235-54 - PubMed
    1. Lancet. 1969 Feb 15;1(7590):326-30 - PubMed
    1. Br J Dermatol. 1969 Oct;81(10):763-5 - PubMed
    1. N Engl J Med. 1972 Apr 13;286(15):808-12 - PubMed

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