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. 1974 Sep;71(9):3659-63.
doi: 10.1073/pnas.71.9.3659.

Organization of immunoglobulin genes: reiteration frequency of the mouse kappa chain constant region gene

T Honjo, S Packman, D Swan, M Nau, P Leder

Organization of immunoglobulin genes: reiteration frequency of the mouse kappa chain constant region gene

T Honjo et al. Proc Natl Acad Sci U S A. 1974 Sep.

Abstract

Hybridization kinetic analyses with synthetic DNA indicate that there are only two to three copies of the kappa constant region gene per haploid genome. This result lends weight to the argument that the immunoglobulin light chain is encoded by more than one continuous gene sequence.

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