doi: 10.1016/0014-2999(79)90419-9.
Denervation supersensitivity to noradrenaline in the guinea-pig vas deferens in vivo: absence of the postjunctional component
- PMID: 421738
- DOI: 10.1016/0014-2999(79)90419-9
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Denervation supersensitivity to noradrenaline in the guinea-pig vas deferens in vivo: absence of the postjunctional component
Eur J Pharmacol.
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Abstract
The effects of denervation and cocaine on the responsiveness of the guinea-pig vas deferens to noradrenaline (NA) were studied. The magnitude of the denervation supersensitivity differed in vivo and in vitro. Cocaine-induced supersensitivity to NA was similar in vivo and in vitro. Only denervation increased the maximum response in experiments in vitro. It is suggested that in the guinea-pig vas deferens the postjunctional component of denervation supersensitivity to NA could result from the experimental conditions involving the isolation procedure.
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