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. 1979 Feb 15;54(1-2):167-71.
doi: 10.1016/0014-2999(79)90419-9.

Denervation supersensitivity to noradrenaline in the guinea-pig vas deferens in vivo: absence of the postjunctional component

P Sannomiya, S De Moraes

Denervation supersensitivity to noradrenaline in the guinea-pig vas deferens in vivo: absence of the postjunctional component

P Sannomiya et al. Eur J Pharmacol. .

Abstract

The effects of denervation and cocaine on the responsiveness of the guinea-pig vas deferens to noradrenaline (NA) were studied. The magnitude of the denervation supersensitivity differed in vivo and in vitro. Cocaine-induced supersensitivity to NA was similar in vivo and in vitro. Only denervation increased the maximum response in experiments in vitro. It is suggested that in the guinea-pig vas deferens the postjunctional component of denervation supersensitivity to NA could result from the experimental conditions involving the isolation procedure.

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