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. 1967 Sep 29;157(3796):1577-8.
doi: 10.1126/science.157.3796.1577.

Erythrocyte abnormality in human myopathy

H D Brown, S K Chattopadhyay, A B Patel

Erythrocyte abnormality in human myopathy

H D Brown et al. Science. .

Abstract

Erythrocyte ghosts isolated from myopathic patients responded to 10(-4) molar ouabain with a dramatic increase in adenosine triphosphatase activity, while identical preparations from normal donors were inhibited by the same drug. These results have been interpreted in terms of a disease-related change in membrane integrity bearing upon function of the transport enzyme.

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