On the regulation of tryptophan metabolism "via" kynurenine
- PMID: 42292
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On the regulation of tryptophan metabolism "via" kynurenine
Acta Vitaminol Enzymol.
1978.
Abstract
The tryptophan leads to nicotinic acid pathway is inhibited in the nicotinic acid administered rats; in this case tryptophan chiefly metabolizes "via" serotonin. The serotonin pathway is inhibited in the excess phenylalanine administered rats, especially due to the inhibition of the tryptophan-5-hydroxylase reaction. Xanthurenic acid inhibits kynurenine-3-hydroxylase in vitro, which is a very important regulatory enzyme for xanthurenic acid and nicotinic acid production.
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