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Clinical Trial
. 1968 Jul 20;3(5611):158-60.
doi: 10.1136/bmj.3.5611.158.

Trial of an anti-inflammatory agent (indomethacin) in low back pain with and without radicular involvement

J H Jacobs, M F Grayson
Clinical Trial

Trial of an anti-inflammatory agent (indomethacin) in low back pain with and without radicular involvement

J H Jacobs et al. Br Med J. .

Abstract

A short-term double-blind sequential trial of indomethacin against placebo in the treatment of low back pain, with and without nerve root pain such as sciatica, showed that indomethacin was significantly more effective than placebo in the group with nerve root pain. On the other hand, no difference was found between the treatments in the patients with uncomplicated low back pain. This difference may result from an effect of indomethacin on the inflammatory process around the nerve root which has been shown to be present when this is compressed.

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References

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