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. 1979 Mar 15;278(5701):227-31.
doi: 10.1038/278227a0.

Structure of the human fetal globin gene locus

P F Little, R A Flavell, J M Kooter, G Annison, R Williamson

Structure of the human fetal globin gene locus

P F Little et al. Nature. .

Abstract

We have derived a 'map' of restriction enzyme sites in and around the human gamma-globin genes. This has enabled us to show that there are two gamma-globin genes per haploid set, that the genes contain 'introns' within the same regions of DNA as the human beta and delta-globin genes, and that the genes are 3,500 base pairs apart. We conclude that the correct gene organisation of the human beta-like globin locus is GgammaAgammadeltabeta.

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