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. 1979 Jan;306(1):97-100.
doi: 10.1007/BF00515601.

The anti-nociceptive effect of reserpine and haloperidol mediated by the nigro-striatal system: antagonism by naloxone

G Heinz, I Jurna

The anti-nociceptive effect of reserpine and haloperidol mediated by the nigro-striatal system: antagonism by naloxone

G Heinz et al. Naunyn Schmiedebergs Arch Pharmacol. 1979 Jan.

Abstract

Reserpine (10 mg/kg) and haloperidol (2 mg/kg) injected intraperitoneally increased the reaction time of the tail-flick response in intact but not in pre-nigrally decerebrate or spinal rats. The antinociceptive effect of both drugs was antagonized by intraperitoneal injections of dopa (100 mg/kg), apomorphine (2 mg/kg) or naloxone (1 mg/kg) as well as by bilateral micro-injections into the caudate nuclei of apomorphine (100 microgram and 20 microgram) and naloxone (10 microgram). It is concluded that the nigrostriatal feedback system is involved in the anti-nociceptive effect of reserpine and haloperidol.

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References

    1. Exp Brain Res. 1976 Mar 15;24(5):473-84 - PubMed
    1. Science. 1976 Jun 25;192(4246):1357-8 - PubMed
    1. Eur J Pharmacol. 1972 Jul;19(1):119-22 - PubMed
    1. Naunyn Schmiedebergs Arch Pharmacol. 1977 Feb;296(3):249-54 - PubMed
    1. Naunyn Schmiedebergs Arch Pharmacol. 1976;292(2):119-26 - PubMed