doi: 10.1126/science.165.3897.1010.
Autosomal trisomy in a chimpanzee: resemblance to Down's syndrome
- PMID: 4240970
- DOI: 10.1126/science.165.3897.1010
Item in Clipboard
Autosomal trisomy in a chimpanzee: resemblance to Down's syndrome
Science.
.
Abstract
An infant chimpanzee (Pan troglodytes) with clinical, behavioral, and cytogenetic features similar to those in Down's syndrome is described. The infant shows retarded growth rate, congenital abnormalities, retarded neurologic and postural development, epicanthus, hyperflexibility of the joints, muscle hypotonia, and trisomy of a small acrocentric chromosome.
Similar articles
-
Trisomy 22 in a calf.Zentralbl Veterinarmed A. 1993 Oct;40(8):576-81. doi: 10.1111/j.1439-0442.1993.tb00669.x. Zentralbl Veterinarmed A. 1993. PMID: 8279206
-
Familial D-D translocation. A family showing transmission through three generations; a case with multiple congenital malformations, and a case of regular 21-trisomic Down's syndrome.Acta Pathol Microbiol Scand. 1969;75(4):545-54. Acta Pathol Microbiol Scand. 1969. PMID: 4246134 No abstract available.
-
Atrioventricular canal associated with trisomy 9.Chest. 1989 Dec;96(6):1420-1. doi: 10.1378/chest.96.6.1420. Chest. 1989. PMID: 2582851
-
Radiological features of the most common autosomal disorders: trisomy 21-22 (mongolism or Down's syndrome), trisomy 18, trisomy 13-15, and the cri du chat syndrome.Clin Radiol. 1971 Oct;22(4):417-33. doi: 10.1016/s0009-9260(71)80108-3. Clin Radiol. 1971. PMID: 4257566 Review. No abstract available.
-
Down's syndrome. Current stage of cytogenetic research.Humangenetik. 1971;12(1):1-28. doi: 10.1007/BF00291028. Humangenetik. 1971. PMID: 4254045 Review. No abstract available.
Cited by
-
Chimpanzee Down syndrome: a case study of trisomy 22 in a captive chimpanzee.Primates. 2017 Apr;58(2):267-273. doi: 10.1007/s10329-017-0597-8. Epub 2017 Feb 21. Primates. 2017. PMID: 28220267
-
Mouse models for Down syndrome-associated developmental cognitive disabilities.Dev Neurosci. 2011;33(5):404-13. doi: 10.1159/000329422. Epub 2011 Aug 25. Dev Neurosci. 2011. PMID: 21865664 Free PMC article. Review.
-
Identification of trisomy in Macaca fascicularis by fluorescence in situ hybridization with a human chromosome 13 DNA library.Hum Genet. 1994 Sep;94(3):247-51. doi: 10.1007/BF00208278. Hum Genet. 1994. PMID: 8076939
-
Ribosomal ribonucleic acids of cultured cells: a preliminary survey of differences among mammalian species detectable by polyacrylamide gel electrophoresis.In Vitro. 1972 Jul-Aug;8(1):13-8. doi: 10.1007/BF02617938. In Vitro. 1972. PMID: 4627803 No abstract available.
-
Origin of human chromosome 21 and its consequences: a 50-million-year-old story.Chromosome Res. 1998 Jun;6(4):263-8. doi: 10.1023/a:1009262622325. Chromosome Res. 1998. PMID: 9688515
MeSH terms
LinkOut - more resources
Full Text Sources
