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. 1979 Jan;6(1):305-19.
doi: 10.1093/nar/6.1.305.

Cytidine 5'-diphosphate reductase activity in phytohemagglutinin stimulated human lymphocytes

G Tyrsted, V Gamulin
Free PMC article

Cytidine 5'-diphosphate reductase activity in phytohemagglutinin stimulated human lymphocytes

G Tyrsted et al. Nucleic Acids Res. 1979 Jan.
Free PMC article

Abstract

The optimal conditions and the effect of deoxyribonucleoside triphosphates were determined for CDP reductase activity in PHA-stimulated lymphocytes. The enzymatic reaction showed an absolute requirement for ATP. In the absence of ATP, only dATP showed a minor stimulation of the reduction of CDP to dCDP. During transformation the CDP reductase activity reached a maximum at the same time as the four deoxyribonucleoside triphosphate pools, corresponding to mid S-phase at about 50 h after PHA addition. The DNA polymerase activity reached a maximum at 57 h.

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