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Clinical Trial
. 1970 Feb 21;1(5694):469-71.
doi: 10.1136/bmj.1.5694.469.

Reduction in incidence of ampicillin rash by purification of ampicillin

E T Knudsen, J M Dewdney, J A Trafford
Clinical Trial

Reduction in incidence of ampicillin rash by purification of ampicillin

E T Knudsen et al. Br Med J. .

Abstract

Purification of ampicillin (Penbritin) with respect to protein impurities has been found significantly to reduce the incidence of rashes in treated patients. This may be related to findings in animals that injections of the isolated protein impurity can induce the formation of circulating IgG antibodies and skin-sensitizing antibodies.

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References

    1. Br Med J. 1966 May 28;1(5499):1359 - PubMed
    1. Lancet. 1967 Jun 3;1(7501):1175-7 - PubMed
    1. Lancet. 1967 Jun 3;1(7501):1177-83 - PubMed
    1. Lancet. 1967 Jun 3;1(7501):1184-8 - PubMed
    1. J Allergy. 1964 Sep-Oct;35:399-424 - PubMed

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