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. 1979 Oct;15(10):789-95.
doi: 10.1007/BF02618305.

Regulation of the induction of alkaline phosphatase in choriocarcinoma cells by sodium butyrate

J Y Chou

Regulation of the induction of alkaline phosphatase in choriocarcinoma cells by sodium butyrate

J Y Chou. In Vitro. 1979 Oct.

Abstract

Alkaline phosphatase is induced in human choriocarcinoma cells by short-chain fatty acids, especially sodium butyrate. This fatty acid increases the phosphatase activity immediately and in a nearly linear fashion. Only phosphatase with an alkaline pH optimum is induced. Both the induced alkaline phosphatase and the basal enzyme are precipitated by antiserum against term-placental alkaline phosphatase, but the choriocarcinoma phosphatase is less stable to heating than is the term-placental enzyme. The induction of alkaline phosphatase activity requires cellular synthesis of protein, RNA and DNA. The regulation of induction probably occurs at the transcriptional level.

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