Thymidylate synthetase: mechanism of inhibition by 5-fluoro-2'-deoxyuridylate
- PMID: 4263280
- DOI: 10.1016/0006-291x(72)90892-3
Thymidylate synthetase: mechanism of inhibition by 5-fluoro-2'-deoxyuridylate
Similar articles
-
Purification and amino acid analysis of an active site peptide from thymidylate synthetase containing covalently bound 5-fluoro-2'-deoxyuridylate and methylenetetrahydrofolate.Biochem Biophys Res Commun. 1974 Apr 8;57(3):689-95. doi: 10.1016/0006-291x(74)90601-9. Biochem Biophys Res Commun. 1974. PMID: 4275130 No abstract available.
-
5-Fluoro-2'-deoxyuridylate: covalent complex with thymidylate synthetase.Proc Natl Acad Sci U S A. 1972 Jul;69(7):1855-7. doi: 10.1073/pnas.69.7.1855. Proc Natl Acad Sci U S A. 1972. PMID: 4505665 Free PMC article.
-
Thymidylate synthetase - a target enzyme in cancer chemotherapy.Biochim Biophys Acta. 1977 Dec 23;473(2):73-92. doi: 10.1016/0304-419x(77)90001-4. Biochim Biophys Acta. 1977. PMID: 145246 Review. No abstract available.
-
Bacteriophage-coded thymidylate synthetase: characteristics of the T4 and T5 enzymes.Arch Biochem Biophys. 1973 Oct;158(2):726-35. doi: 10.1016/0003-9861(73)90567-5. Arch Biochem Biophys. 1973. PMID: 4273803 No abstract available.
-
Fluorinated pyrimidines as tight-binding inhibitors of thymidylate synthetase.Pharmacol Ther. 1981;13(1):69-90. doi: 10.1016/0163-7258(81)90068-1. Pharmacol Ther. 1981. PMID: 6455671 Review. No abstract available.
Cited by
-
Relative level of thymidylate synthase mRNA expression in primary tumors and normal tissues predicts survival of patients with oral tongue squamous cell carcinoma.Eur Arch Otorhinolaryngol. 2010 Apr;267(4):581-6. doi: 10.1007/s00405-009-1062-0. Epub 2009 Aug 21. Eur Arch Otorhinolaryngol. 2010. PMID: 19697054
-
Clinical significance of dihydropyrimidine dehydrogenase in adjuvant 5-fluorouracil liver perfusion chemotherapy for pancreatic cancer.Ann Surg. 2004 Nov;240(5):840-4. doi: 10.1097/01.sla.0000143300.49878.51. Ann Surg. 2004. PMID: 15492566 Free PMC article.
-
Sequence-specific and mechanism-based crosslinking of Dcm DNA cytosine-C5 methyltransferase of E. coli K-12 to synthetic oligonucleotides containing 5-fluoro-2'-deoxycytidine.Nucleic Acids Res. 1993 Jan 25;21(2):303-9. doi: 10.1093/nar/21.2.303. Nucleic Acids Res. 1993. PMID: 8441638 Free PMC article.
-
Promotion of purine nucleotide binding to thymidylate synthase by a potent folate analogue inhibitor, 1843U89.Proc Natl Acad Sci U S A. 1995 Apr 11;92(8):3493-7. doi: 10.1073/pnas.92.8.3493. Proc Natl Acad Sci U S A. 1995. PMID: 7724588 Free PMC article.
-
Effects of oxaliplatin and CPT-11 on cytotoxicity and nucleic acid incorporation of the fluoropyrimidines.J Cancer Res Clin Oncol. 2004 Aug;130(8):453-9. doi: 10.1007/s00432-004-0575-6. Epub 2004 Jun 15. J Cancer Res Clin Oncol. 2004. PMID: 15205948 Free PMC article.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources