Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1973 May 1;137(5):1303-9.
doi: 10.1084/jem.137.5.1303.

Cell-mediated lympholysis. Importance of serologically defined H-2 regions

B J Alter, D J Schendel, M L Bach, F H Bach, J Klein, J H Stimpfling

Cell-mediated lympholysis. Importance of serologically defined H-2 regions

B J Alter et al. J Exp Med. .

Abstract

The cell-mediated lympholytic capability of mouse spleen cells stimulated in mixed lymphocyte culture is related to the major histocompatibility complex genotype on target lymphocytes. The strain combinations AQR-B10. T(6R) and B10.A(4R)-B10.A(2R) that result in significant mixed lymphocyte culture activation do not mediate cell-mediated lympholysis on sensitizing target lymphocytes; serologically defined regions (H-2K and H-2D) are identical within each combination. H-2K or H-2D region disparity alone does not cause cell-mediated lympholysis. However after mixed lymphocyte culture activation as seen with B10.A-B10.T(6R), a target cell bearing only an H-2K region difference from the effector cell is sensitive to cell-mediated lympholysis. Likewise an H-2D region difference is an adequate target after mixed lymphocyte culture activation of the effector cell in the combination B10.A(2R)-B10.D2.

PubMed Disclaimer

References

    1. J Exp Med. 1966 Apr 1;123(4):665-71 - PubMed
    1. J Exp Med. 1968 Oct 1;128(4):623-37 - PubMed
    1. Biochem Genet. 1970 Jun;4(3):351-65 - PubMed
    1. Proc Natl Acad Sci U S A. 1971 Dec;68(12):3031-5 - PubMed
    1. Transplant Rev. 1971;6:3-29 - PubMed

Substances