doi: 10.1002/art.1780220406.
Collagen-induced arthritis in rats. Comparison of vitreous and cartilage-derived collagens
- PMID: 426881
- DOI: 10.1002/art.1780220406
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Collagen-induced arthritis in rats. Comparison of vitreous and cartilage-derived collagens
Arthritis Rheum.
1979 Apr.
Abstract
An oil emulsion of purified type II collagen from bovine articular cartilage when injected intradermally into rats induced an inflammatory polyarthritis in 4 of 12 animals. When similarly injected, collagen purified from bonve vitreous induced arthritis in 6 of 12 animals. Studies of humoral and cell-mediated immunity to both collagen preparations demonstrated complete cross-reactivity. It is concluded that vitreous collagen shares the arthritogenic property of cartilage-derived type II collagen and that collagen from the two sources is indistinguishable in arthritogenic and immunologic properties.
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