Enzyme changes in experimental renal microcystic disease
- PMID: 4271322
- PMCID: PMC2072560
Enzyme changes in experimental renal microcystic disease
Abstract
In an experimental model of human microcystic disease in rats, abnormal changes in tubular enzyme activity were detected as the lesion developed. Decreased activity for alkaline phosphatase, Mg++-ATPase, and Na+K+-ATPase were detected mainly in the proximal tubule, where the lesion was most pronounced. Areas of early fibrosis between the cystic tubules were associated with acid phosphatase activity.
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