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. 1979 Mar;65(3):483-8.
doi: 10.1111/j.1476-5381.1979.tb07855.x.

Action of colchicine and cytochalasin B on the acetylcholine receptor

R Anwyl, T Narahashi

Action of colchicine and cytochalasin B on the acetylcholine receptor

R Anwyl et al. Br J Pharmacol. 1979 Mar.

Abstract

1. The effects of colchicine and cytochalasin B have been investigated on the extrajunctional acetylcholine (ACh) receptors of rat muscle. 2. Colchicine and cytochalasin B each decreased the amplitude and rise time of the iontophoretic ACh potential. When the dose of ACh was increased in the presence of these agents, ACh potentials were produced with a biphasic waveform consisting of a fast initial phase and a second slow phase. 3. It is proposed that colchicine and cytochalasin B are acting through a mechanism other than the breakdown of microtubules and microfilaments.

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