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. 1973 Nov;70(11):3155-9.
doi: 10.1073/pnas.70.11.3155.

Assembly of the mitochondrial system. Purification of a mitochondrial product of the ATPase

M F Sierra, A Tzagoloff

Assembly of the mitochondrial system. Purification of a mitochondrial product of the ATPase

M F Sierra et al. Proc Natl Acad Sci U S A. 1973 Nov.

Abstract

A low-molecular-weight protein synthesized in yeast mitochondria was purified. The protein was identified as a component of the rutamycin-sensitive ATPase. The amino-acid composition of the purified protein shows an extremely large preponderance of nonpolar residues, which may account for its solubility in chloroform-methanol. Indirect evidence suggests that this component is involved in the conferral of rutamycin sensitivity and may also have a function in the assembly of the ATPase complex.

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