Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1974 May;37(5):502-13.
doi: 10.1136/jnnp.37.5.502.

Nodal gap substance in diabetic nerve

K N Seneviratne, A Weerasuriya

Nodal gap substance in diabetic nerve

K N Seneviratne et al. J Neurol Neurosurg Psychiatry. 1974 May.

Abstract

Anoxia and KC1 have been used to inactivate peripheral nerves by depolarization conduction block. Investigation of the inactivation patterns in isolated sciatic nerves of healthy and alloxan-diabetic rats suggests that the paranodal gap substance of healthy nerve behaves as an effective periaxonal diffusion barrier. In diabetic nerve the permeability of this barrier is significantly increased. A marked reduction in the K' binding capacity of the nodal gap substance has been demonstrated in myelinated nerves of human diabetics and alloxan diabetic rats.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

References

    1. Science. 1970 May 1;168(3931):596-8 - PubMed
    1. Z Zellforsch Mikrosk Anat. 1968;89(1):95-111 - PubMed
    1. Proc R Soc Lond B Biol Sci. 1952 Nov 20;140(900):301-20 - PubMed
    1. J Neuropathol Exp Neurol. 1971 Jan;30(1):105-19 - PubMed
    1. Biochem J. 1963 Nov;89:249-53 - PubMed

MeSH terms

LinkOut - more resources