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. 1974 Jun;71(6):2449-52.
doi: 10.1073/pnas.71.6.2449.

Effects of an antibody to a highly purified Na+, K+-ATPase from canine renal medulla: separation of the "holoenzyme antibody" into catalytic and cardiac glycoside receptor-specific components

J L McCans, L K Lane, G E Lindenmayer, V P Butler Jr, A Schwartz

Effects of an antibody to a highly purified Na+, K+-ATPase from canine renal medulla: separation of the "holoenzyme antibody" into catalytic and cardiac glycoside receptor-specific components

J L McCans et al. Proc Natl Acad Sci U S A. 1974 Jun.

Abstract

An antiserum was prepared against a highly purified Na(+), K(+)-adenosine triphosphatase (ATP phosphohydrolase, EC 3.6.1.3). Purification and fractionation yielded two globulin components, one of which appears specific for a digitalis glycoside receptor site or binding conformation and the other for a catalytic site or conformation.

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