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. 1974 Feb;26(2):303-10.

Effector activating determinants on IgG. II. Differentiation of the combining sites for C1q from those for cytotoxic K cells and neutrophils by plasmin digestion of rabbits IgG

I C MacLennan, G E Connell, F M Gotch

Effector activating determinants on IgG. II. Differentiation of the combining sites for C1q from those for cytotoxic K cells and neutrophils by plasmin digestion of rabbits IgG

I C MacLennan et al. Immunology. 1974 Feb.

Abstract

Plasmin digestion of rabbit IgG after pretreatment at low pH yields a fragment (Facb) which has lost the CH3 domain. A study of the biological activity of this fragment is described and the following conclusions are drawn: (1) Facb possesses the same antigen-combining capacity as the whole antibody; (2) C1 fixation is normal; (3) The capacity to sensitize target cells to lysis by cytotoxic K cells is lost; (4) Facb—antigen complexes are unable competitively to inhibit phagocytosis of sensitized bacteria by neutrophils.

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