Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1979 Feb;24(2):123-8.
doi: 10.1007/BF01324739.

Effect of ursodeoxycholic acid administration on biliary lipid composition and bile acid kinetics in cholesterol gallstone patients

E Roda, A Roda, C Sama, D Festi, G Mazzella, R Aldini, L Barbara

Effect of ursodeoxycholic acid administration on biliary lipid composition and bile acid kinetics in cholesterol gallstone patients

E Roda et al. Dig Dis Sci. 1979 Feb.

Abstract

The effect of ursodeoxycholic acid (UDCA) on bile lipid composition and bile acid kinetics was evaluated in seven cholesterol gallstone patients following one month of UDCA administration (12 mg/kg/day). UDCA administration induces a significant reduction in the cholesterol saturation index (SI). After UDCA treatment, UDCA becomes the predominant biliary bile acid while chenodeoxycholic, cholic, and deoxycholic acid are significantly reduced. UDCA pool significantly increases, and chenodeoxycholic, cholic, and total bile acid pools significantly decrease. The reduction in bile lithogenicity during UDCA administration suggests that UDCA may be useful for cholesterol gallstone treatment in man.

PubMed Disclaimer

References

    1. Clin Chim Acta. 1975 Nov 3;64(3):337-41 - PubMed
    1. J Clin Invest. 1973 Nov;52(11):2809-21 - PubMed
    1. Digestion. 1976;14(3):209-19 - PubMed
    1. N Engl J Med. 1975 Aug 21;293(8):378-83 - PubMed
    1. N Engl J Med. 1975 Mar 20;292(12):604-7 - PubMed

MeSH terms