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. 1966 Jul 1;124(1):99-114.
doi: 10.1084/jem.124.1.99.

Crystal-induced inflammation in canine joints. I. An experimental model with quantification of the host response

D J McCarty Jr, P Phelps, J Pyenson

Crystal-induced inflammation in canine joints. I. An experimental model with quantification of the host response

D J McCarty Jr et al. J Exp Med. .

Abstract

Injection of sodium urate or calcium pyrophosphate crystals into the stifle joints of anesthetized dogs almost invariably induced an acute exudative response. This response was quantified by serial measurements of intra-articular pressure, pH and leukocyte concentration. Pressure rose progressively and reflected intra-articular volume increase. The hydrogen ion concentration increased as the reaction progressed and correlated in a given exudate with the leukocyte concentration. Analysis of sequential physiologic and biochemical changes occurring in this model of crystal-induced inflammation may provide insight into the mechanisms of acute gouty arthritis in man.

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References

    1. J Exp Med. 1966 Jul 1;124(1):115-26 - PubMed
    1. Ann Intern Med. 1961 Mar;54:452-60 - PubMed
    1. Physiol Rev. 1962 Jan;42:143-68 - PubMed
    1. Ann Intern Med. 1962 May;56:738-45 - PubMed
    1. Curr Ther Res Clin Exp. 1963 May;5:284-90 - PubMed