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. 1979 Feb;20(2):121-5.
doi: 10.1136/gut.20.2.121.

Absorption of antigens after oral immunisation and the simultaneous induction of specific systemic tolerance

E T Swarbrick, C R Stokes, J F Soothill

Absorption of antigens after oral immunisation and the simultaneous induction of specific systemic tolerance

E T Swarbrick et al. Gut. 1979 Feb.

Abstract

Antigenic proteins may be absorbed intact. We report here results from in vivo experiments in mice showing that the prior feeding of protein antigen may reduce the subsequent absorption of that antigen without altering its elimination from the circulation. This may be a function of local immunity. We have also shown that the same feeding regime can paradoxically induce a state of systemic tolerance and suggest that the two phenomena contribute to the safe handling of these antigens.

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References

    1. Nature. 1962 May 5;194:495-6 - PubMed
    1. Lancet. 1977 Feb 12;1(8007):321-4 - PubMed
    1. Biochem Soc Trans. 1977;5(5):1571-3 - PubMed
    1. Cell Immunol. 1977 Sep;33(1):145-55 - PubMed
    1. Arch Dis Child. 1975 Jul;50(7):532-4 - PubMed

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