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. 1966 Nov 25;154(3752):1053-5.
doi: 10.1126/science.154.3752.1053.

Vesicular stomatitis virus replication in human leukocyte cultures: enhancement by phytohemagglutinin

R Edelman, E F Wheelock

Vesicular stomatitis virus replication in human leukocyte cultures: enhancement by phytohemagglutinin

R Edelman et al. Science. .

Abstract

The replication of vesicular stomatitis virus in human leukocyte cultures shows that virus yields can be enhanced 6-to 180-fold by treating the leukocyte cultures with phytohemagglutinin prior to virus inoculation. Data suggest that a substance is produced in phytohemagglutinin-treated leukocyte cultures which is capable, on transfer to fresh leukocytes, of inducing blast cell formation and enhancing virus replication.

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