doi: 10.1128/jb.93.1.207-214.1967.
Bacterial metabolism of mevalonic acid
- PMID: 4289807
- PMCID: PMC314990
- DOI: 10.1128/jb.93.1.207-214.1967
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Bacterial metabolism of mevalonic acid
J Bacteriol.
1967 Jan.
Abstract
Soluble cell-free extracts of actinomycete S4 grown on media containing mevalonate catalyze acetoacetate formation from mevalonate, mevaldate, and beta-hydroxy-beta-methylglutaryl-coenzyme A (CoA). Conversion of mevalonate to acetoacetate involves formation of free beta-hydroxy-beta-methylglutaryl-CoA, but not free mevaldate. The reaction favors mevalonate oxidation, and nicotinamide adenine dinucleotide, rather than nicotinamide adenine dinucleotide phosphate, acts as oxidant.
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