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. 1967 Jan;93(1):207-14.
doi: 10.1128/jb.93.1.207-214.1967.

Bacterial metabolism of mevalonic acid

M A Siddiqi, V W Rodwell

Bacterial metabolism of mevalonic acid

M A Siddiqi et al. J Bacteriol. 1967 Jan.

Abstract

Soluble cell-free extracts of actinomycete S4 grown on media containing mevalonate catalyze acetoacetate formation from mevalonate, mevaldate, and beta-hydroxy-beta-methylglutaryl-coenzyme A (CoA). Conversion of mevalonate to acetoacetate involves formation of free beta-hydroxy-beta-methylglutaryl-CoA, but not free mevaldate. The reaction favors mevalonate oxidation, and nicotinamide adenine dinucleotide, rather than nicotinamide adenine dinucleotide phosphate, acts as oxidant.

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