doi: 10.1007/BF00278902.
Sister chromatid exchanges and aging. III. The effect of donor age on mutagen-induced sister chromatid exchange in human diploid fibroblasts
- PMID: 429008
- DOI: 10.1007/BF00278902
Item in Clipboard
Sister chromatid exchanges and aging. III. The effect of donor age on mutagen-induced sister chromatid exchange in human diploid fibroblasts
Hum Genet.
.
Abstract
Although baseline levels of SCE appear to be similar in metaphase cells derived from young and old human skin fibroblast cultures, a significant decline in both MMC- and AAAF-induced sister chromatid exchanges was observed in the older cell populations. Considerable variation exists in the levels of MMC-induced SCE between individual cell cultures. However, parallel examination of several cell strains from young and old donors confirmed the decrease in mutagen-induced SCE frequencies in older cell populations.
Similar articles
-
Factors influencing the frequency of mitomycin C-induced sister-chromatid exchanges in 5-bromodeoxyuridine-substituted human lymphocytes in culture.Mutat Res. 1978 Sep;51(3):411-8. doi: 10.1016/0027-5107(78)90129-x. Mutat Res. 1978. PMID: 362180
-
The effect of aging on sister chromatid exchange.Mech Ageing Dev. 1979 Feb;9(3-4):303-11. doi: 10.1016/0047-6374(79)90107-6. Mech Ageing Dev. 1979. PMID: 374898 Review.
-
Aging and sister chromatid exchange. II. The effect of the in vitro passage level of human fetal lung fibroblasts on baseline and mutagen-induced sister chromatid exchange frequencies.Exp Cell Res. 1978 Sep;115(2):269-76. doi: 10.1016/0014-4827(78)90281-1. Exp Cell Res. 1978. PMID: 689083 No abstract available.
-
Effects of caffeine on chromosome aberrations and sister-chromatid exchanges induced by mitomycin C in BrdU-labeled human chromosomes.Mutat Res. 1979 Aug;62(1):139-49. doi: 10.1016/0027-5107(79)90227-6. Mutat Res. 1979. PMID: 91107
-
Sister-chromatid exchanges: a report of the GENE-TOX program.Mutat Res. 1981 Jul;87(1):17-62. doi: 10.1016/0165-1110(81)90003-8. Mutat Res. 1981. PMID: 6173747 Review.
Cited by
-
Cell culture aging.Mol Cell Biochem. 1981 May 26;36(3):169-76. doi: 10.1007/BF02357034. Mol Cell Biochem. 1981. PMID: 7019665 Review.
-
Variation in the sensitivity of human lymphocytes to DNA-damaging agents measured by sister chromatid exchange frequency.Hum Genet. 1982;60(1):19-23. doi: 10.1007/BF00281257. Hum Genet. 1982. PMID: 7076244
-
The effect of donor sex and age on the number of sister chromatid exchanges in human lymphocytes growing in vitro.Hum Genet. 1981;57(1):83-5. doi: 10.1007/BF00271174. Hum Genet. 1981. PMID: 7262873
-
Sister chromatid exchange frequencies in Progeria and Werner syndrome patients.Am J Hum Genet. 1981 Sep;33(5):762-6. Am J Hum Genet. 1981. PMID: 7294025 Free PMC article.
-
Cytogenetics and cytokinetics of cultured lymphocytes from benzene-exposed workers.Int Arch Occup Environ Health. 1980;46(1):31-41. doi: 10.1007/BF00377457. Int Arch Occup Environ Health. 1980. PMID: 7380571 No abstract available.