Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1979 Jan 19;46(1):57-63.
doi: 10.1007/BF00278902.

Sister chromatid exchanges and aging. III. The effect of donor age on mutagen-induced sister chromatid exchange in human diploid fibroblasts

E L Schneider, B Gilman

Sister chromatid exchanges and aging. III. The effect of donor age on mutagen-induced sister chromatid exchange in human diploid fibroblasts

E L Schneider et al. Hum Genet. .

Abstract

Although baseline levels of SCE appear to be similar in metaphase cells derived from young and old human skin fibroblast cultures, a significant decline in both MMC- and AAAF-induced sister chromatid exchanges was observed in the older cell populations. Considerable variation exists in the levels of MMC-induced SCE between individual cell cultures. However, parallel examination of several cell strains from young and old donors confirmed the decrease in mutagen-induced SCE frequencies in older cell populations.

PubMed Disclaimer

References

    1. Chromosoma. 1974;48(3):327-40 - PubMed
    1. Proc Natl Acad Sci U S A. 1973 Dec;70(12):3395-9 - PubMed
    1. Biochem Biophys Res Commun. 1974 Aug 5;59(3):850-7 - PubMed
    1. Proc Natl Acad Sci U S A. 1978 Mar;75(3):1353-6 - PubMed
    1. Mutat Res. 1975 Nov;30(2):273-8 - PubMed