Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1967 May;15(3):657-60.
doi: 10.1128/am.15.3.657-660.1967.

Production of high-titer antibody in serum and ascitic fluid of hamsters for a variety of virus-induced tumor antigens

R V Gilden, T G Beddow, R J Huebner

Production of high-titer antibody in serum and ascitic fluid of hamsters for a variety of virus-induced tumor antigens

R V Gilden et al. Appl Microbiol. 1967 May.

Abstract

Methods not involving the use of viable tumors were developed for production of high-titer antibodies. The methods involved use of tumor homogenates. Homogenates from all tumor lines tested contained the characteristic tumor antigen. Attempts to isolate virus failed, and virus antigens could not be demonstrated. Immunization with tumor homogenates, in Freund's complete adjuvant, resulted in high antibody levels. None of the animals so immunized developed tumors.

PubMed Disclaimer

References

    1. Proc Soc Exp Biol Med. 1965 Oct;120(1):124-7 - PubMed
    1. Proc Natl Acad Sci U S A. 1965 Aug;54(2):381-8 - PubMed
    1. J Immunol. 1962 Mar;88:320-9 - PubMed
    1. Proc Natl Acad Sci U S A. 1963 Aug;50:379-89 - PubMed
    1. Proc Natl Acad Sci U S A. 1964 May;51:742-50 - PubMed

LinkOut - more resources