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. 1967 Sep 15;157(3794):1324-5.
doi: 10.1126/science.157.3794.1324.

Tissue specificity of histone phosphorylation

R M Gutierrez, L S Hnilica

Tissue specificity of histone phosphorylation

R M Gutierrez et al. Science. .

Abstract

The incorporation of (32)P-phosphate into histone fractions isolated from normal, hepatectomized, and Novikoff hepatoma-bearing rats was investigated. Varying degrees of phosphorylation were exhibited by different histone fractions. The phosphorylation of histones is tissue specific and appears to be correlated with metabolic cell functions, that is, it decreases with increasing mitotic activity of the cells.

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