Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1968 Jan 26;159(3813):431-2.
doi: 10.1126/science.159.3813.431.

Specific inhibition of viral ribonucleic acid replication by Gliotoxin

P A Miller, K P Milstrey, P W Trown

Specific inhibition of viral ribonucleic acid replication by Gliotoxin

P A Miller et al. Science. .

Abstract

Gliotoxin inhibits intracellular replication of poliovirus in HeLa cells at a stage subsequent to adsorption and penetration of virus. The sensitive step is synthesis of viral RNA: synthesis of viral protein is unaffected except as a consequence of blockade of RNA synthesis. Concentrations of gliotoxin sufficient to block viral RNA synthesis completely do not affect cellular RNA synthesis.

PubMed Disclaimer

LinkOut - more resources