doi: 10.1126/science.162.3857.1024.
Basis for the acquisition of malignant potential by mouse cells cultivated in vitro
- PMID: 4301647
- DOI: 10.1126/science.162.3857.1024
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Basis for the acquisition of malignant potential by mouse cells cultivated in vitro
Science.
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Abstract
Balb/c mouse embryo lines maintained in culture for over 200 generations under conditions that minimize cell-cell contact do not become tumorigenic. Lines cultivated under conditions where there is extensive cell contact become tumor-producing within 30 generations. The tissue-culture property that correlates best with tumorigenicity is the loss of contact inhibition of cell division.
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