Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1969 May;48(5):930-9.
doi: 10.1172/JCI106052.

Plasma progesterone and 17-hydroxyprogesterone in normal men and children with congenital adrenal hyperplasia

C A Strott, T Yoshimi, M B Lipsett

Plasma progesterone and 17-hydroxyprogesterone in normal men and children with congenital adrenal hyperplasia

C A Strott et al. J Clin Invest. 1969 May.

Abstract

Plasma 17-hydroxyprogesterone (17-OHP) concentrations in normal men averaged 0.094 mug/100 ml. Studies using suppressive doses of androgens and glucocorticoids showed that 90% of the 17-OHP originated from the Leydig cell. The 17-OHP production rate was 1.8 mg/24 hr. Plasma 17-OHP has a marked circadian variation, the 8 p.m. values being only 40% of the 8 a.m. values. Plasma luteinizing hormone measured in the same samples did not vary. The adrenal cortex has the capacity to synthesize and secrete 17-OHP and progesterone since adrenocorticotrophic hormone (ACTH) caused a fourfold increase in these plasma steroids. In children with congenital adrenal hyperplasia, plasma 17-OHP levels were 50-200 times those of normal men and plasma progesterone was increased 6- to 10-fold over normal men.

PubMed Disclaimer

References

    1. J Clin Endocrinol Metab. 1965 Nov;25(11):1441-50 - PubMed
    1. Bull Soc Chim Biol (Paris). 1965;47(11):2145-61 - PubMed
    1. J Clin Endocrinol Metab. 1966 May;26(5):573-6 - PubMed
    1. J Clin Invest. 1967 Feb;46(2):248-55 - PubMed
    1. J Clin Endocrinol Metab. 1966 Dec;26(12):1297-302 - PubMed

MeSH terms