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. 1969 Apr;17(4):611-3.
doi: 10.1128/am.17.4.611-613.1969.

Microneutralization test for determination of rhinovirus and coxsackievirus A antibody in human diploid cells

R L Kriel, H Wulff, T D Chin

Microneutralization test for determination of rhinovirus and coxsackievirus A antibody in human diploid cells

R L Kriel et al. Appl Microbiol. 1969 Apr.

Abstract

A method for determination of serum-neutralizing antibody titers to rhinovirus type 16 and coxsackievirus type A-4 in human diploid cells (WI-38) grown in Microtiter plates is described. A good correlation was observed when comparing neutralization tests in WI-38 and other cells. The WI-38 Microtiter method is relatively simple and economical. It is suitable for those laboratories which are required to conduct large-scale serological evaluation of antibodies for rhinoviruses and coxsackie A viruses. This system also can be used for cytomegalovirus and varicella-zoster virus, which grow relatively slowly.

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References

    1. Proc Soc Exp Biol Med. 1966 Aug-Sep;122(4):1137-41 - PubMed
    1. Am J Epidemiol. 1967 May;85(3):424-37 - PubMed
    1. Proc Soc Exp Biol Med. 1961 Jul;107:544-6 - PubMed

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