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. 1969 Aug 1;165(3892):513-5.
doi: 10.1126/science.165.3892.513.

Human growth hormone release: relation to slow-wave sleep and sleep-walking cycles

J F Sassin, D C Parker, J W Mace, R W Gotlin, L C Johnson, L G Rossman

Human growth hormone release: relation to slow-wave sleep and sleep-walking cycles

J F Sassin et al. Science. .

Abstract

Release of human growth hormone during sleep is significantly related to slow, synchronized stages of sleep and therefore would seem to be controlled by related neural mechanisms. When sleep-waking cycles are reversed by 12 hours, the release of growth hormone with sleep is reversed; thus release does not follow an inherent circadian rhythm independent of sleep.

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