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. 1969 Jun;17(6):866-70.
doi: 10.1128/am.17.6.866-870.1969.

Yellow fever vaccine. II. Antigenicity and neurovirulence of a vaccine seed free from avian leukosis virus

N M Tauraso, S L Spector, R L Kirschstein, E B Seligmann Jr, J F Farber

Yellow fever vaccine. II. Antigenicity and neurovirulence of a vaccine seed free from avian leukosis virus

N M Tauraso et al. Appl Microbiol. 1969 Jun.

Abstract

Avian leukosis virus (ALV)-free candidate primary and secondary seed lots were indistinguishable from corresponding ALV-contaminated lots with respect to (i) potency as measured by titration in newborn and weanling mice and in the MA-104 plaque system, (ii) degree of viscerotropism as measured by viremia in monkeys, (iii) neurotropism as determined by the monkey neurovirulence test, and (iv) potency as determined by antibody response in monkeys inoculated by the intracerebral route.

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References

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