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. 1968 Mar 29;159(3822):1483-5.
doi: 10.1126/science.159.3822.1483.

Human granulocyte collagenase

G S Lazarus, R S Brown, J R Daniels, H M Fullmer

Human granulocyte collagenase

G S Lazarus et al. Science. .

Abstract

A collagenase, operative at neutral and alkaline pH, has been extracted from the granule fraction of human granulocytic leukocytes. It digests reconstituted collagen fibrils and reduces the viscosity of collagen solutions. Cleavage of collagen in solution with purified enzyme produces the discrete products characteristic of other animal collagenases.

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