doi: 10.1073/pnas.62.3.994.
A difference in the architecture of the surface membrane of normal and virally transformed cells
- PMID: 4308100
- PMCID: PMC223697
- DOI: 10.1073/pnas.62.3.994
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A difference in the architecture of the surface membrane of normal and virally transformed cells
Proc Natl Acad Sci U S A.
1969 Mar.
Abstract
Several tissue culture cell lines that were transformed by a tumor virus have been found to react with an agglutinin, while under identical conditions their untransformed parent cell lines did not agglutinate. Since a short treatment of the parent cell line with low concentrations of proteases exposed the same agglutinin receptor sites in a fashion indistinguishable from the transformed cells, it is proposed that both viral and chemical transformation produce changes in the architecture of the membrane, identical to those of the proteases.
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