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. 1969 Oct 17;166(3903):390-1.
doi: 10.1126/science.166.3903.390.

Human diploid cell transformation by DNA extracted from the tumor virus SV40

S Aaronson, S Todaro

Human diploid cell transformation by DNA extracted from the tumor virus SV40

S Aaronson et al. Science. .

Abstract

The DNA isolated from simian virus 40 (SV40) can transform human fibroblast cells in tissue culture. Clonal lines of DNA-transformed human cells have been obtained that have properties characteristic of cells transformed by whole virus. They all contain SV40 T-antigen, and infectious virus can be recovered by cocultivation. This is the first demonstration of a permanent genetic alteration produced in human cells by purified DNA.

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