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. 1969 Oct 24;166(3904):510-2.
doi: 10.1126/science.166.3904.510.

Synaptic current at the squid giant synapse

P W Gage, J W Moore

Synaptic current at the squid giant synapse

P W Gage et al. Science. .

Abstract

Transmission in the giant synapse of squid was studied by measuring synaptic currents in the voltage-clamped postsynaptic giant axon. These currents varied linearly with the axon's membrane potential, and showed an intercept on the voltage axis at, or near, the sodium equilibrium potential. The intercept shifted in seawater containing less sodium by even more than the shift in the sodium equilibrium potential. It is concluded that the transmitter at this synapse causes a significant change in the sodium conductance only.

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