Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1969 Sep 10;36(6):965-72.
doi: 10.1016/0006-291x(69)90298-8.

Platelet aggregation. I. Regulation by cyclic AMP and prostaglandin E1

N R Marquis, R L Vigdahl, P A Tavormina

Platelet aggregation. I. Regulation by cyclic AMP and prostaglandin E1

N R Marquis et al. Biochem Biophys Res Commun. .

Abstract

PIP: Platelet aggregation plays a major role in thrombogenesis. This study was undertaken to examine the inhibition of platelet aggregation induced by adenosine diphosphate. It is known that cyclic AMP (adenosine monophosphate) and its dibutyryl derivative inhibit platelet aggregation. This study showed that prostaglandin E1 (PGE1) also inhibits platelet aggregation and stimulates cyclic AMP synthesis by stimulation of adenyl cyclose. Caffeine, on the other hand, inhibits platelet phosphodiesterase, and increases cyclic AMP levels. PGA1 and PGF1 alpha can also inhibit platelet aggregation but only at very high concentrations.

PubMed Disclaimer

MeSH terms

LinkOut - more resources