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. 1969 Nov 21;166(3908):1007-8.
doi: 10.1126/science.166.3908.1007.

Polyol pathway in aorta: regulation by hormones

R S Clements Jr, A D Morrison, A I Winegrad

Polyol pathway in aorta: regulation by hormones

R S Clements Jr et al. Science. .

Abstract

Aldose reductase is present in human and rabbit aortas and provides a mechanism whereby hyper-glycemia can alter the metabolism of the arterial wall. Aortic sorbitol concentration is regulated by ambient glucose concentration and is increased by epinephrine, isoproterenol, dibutyryl-3',5'-adenosine monophosphate, ouabain, and angiotensin II.

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