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. 1969 Aug;63(4):1128-35.
doi: 10.1073/pnas.63.4.1128.

A nondefective (competent) adenovirus-SV40 hybrid isolated from the AD.2-SV40 hybrid population

A M Lewis Jr, M J Levin, W H Wiese, C S Crumpacker, P H Henry

A nondefective (competent) adenovirus-SV40 hybrid isolated from the AD.2-SV40 hybrid population

A M Lewis Jr et al. Proc Natl Acad Sci U S A. 1969 Aug.

Abstract

A new nondefective hybrid virus has been plaque-isolated from the Ad.2-SV40 hybrid population. This virus replicates efficiently with one-hit kinetics in both human embryonic kidney and African green monkey kidney cells, induces an SV40 specific antigen which is detectable by immunofluorescence and complement-fixation using sera from SV40 tumor-bearing hamsters, and produces SV40-specific RNA detectable by DNA-RNA hybridization. The SV40-specific antigen induced by this virus is heat-stable, sensitive to inhibitors of DNA synthesis, serologically different from SV40 T and viral antigens, and is an unrecognized SV40 antigen.

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