doi: 10.1073/pnas.63.4.1144.
Biochemical evidence for induction by polyoma virus of replication of the chromosomes of mouse kidney cells
- PMID: 4311251
- PMCID: PMC223441
- DOI: 10.1073/pnas.63.4.1144
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Biochemical evidence for induction by polyoma virus of replication of the chromosomes of mouse kidney cells
Proc Natl Acad Sci U S A.
1969 Aug.
Abstract
It was shown earlier that in cultures of contact-inhibited mouse kidney cells infection with polyoma virus induces replication of the chromosomal DNA. In this paper we present evidence, based on analyses of isolated chromatin, that, parallel with and as a consequence of the virus-induced synthesis of cellular DNA, the chromosomal proteins are synthesized in the proportions characteristic of normal chromosome replication. These results are compatible with the hypothesis that polyoma virus activates (or derepresses) a regulatory system of the host cell which controls initiation of chromosome replication.
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