Identification of an NAD(P)+-dependent 'malic' enzyme in small-intestinal-mucosal mitochondria
- PMID: 43139
- PMCID: PMC1161692
- DOI: 10.1042/bj1840185
Identification of an NAD(P)+-dependent 'malic' enzyme in small-intestinal-mucosal mitochondria
Abstract
An NAD(P)+-dependent 'malic' enzyme is shown to be present in mitochondria from small-intestinal mucosa. The intracellular location, activity and regulatory kinetic properties of the enzyme suggest that it participates in the major energy-producing pathway for net oxidation of glutamine-derived tricarboxylic acid-cycle intermediates.
Similar articles
-
Mitochondrial malic enzymes. Purification and properties of the NAD(P)-dependent malic enzyme from canine small intestinal mucosa.J Biol Chem. 1982 Oct 25;257(20):12405-11. J Biol Chem. 1982. PMID: 7118947
-
Isolation and properties of a 'malic' enzyme from cauliflower bud mitochondria.Biochem J. 1971 May;122(4):495-501. doi: 10.1042/bj1220495. Biochem J. 1971. PMID: 4399380 Free PMC article.
-
Mitochondrial malic enzymes. An association between NAD(P)+-dependent malic enzyme and cell renewal in Sprague-Dawley rat tissues.J Biol Chem. 1980 May 10;255(9):3849-54. J Biol Chem. 1980. PMID: 7372653
-
Malate decarboxylases: evolution and roles of NAD(P)-ME isoforms in species performing C(4) and C(3) photosynthesis.J Exp Bot. 2011 May;62(9):3061-9. doi: 10.1093/jxb/err024. Epub 2011 Mar 31. J Exp Bot. 2011. PMID: 21459769 Review.
-
Role of NAD(+)-dependent 'malic' enzyme and pyruvate dehydrogenase complex in leaf metabolism.Biochem Soc Trans. 1996 Aug;24(3):743-6. doi: 10.1042/bst0240743. Biochem Soc Trans. 1996. PMID: 8878838 Review. No abstract available.
Cited by
-
High malic enzyme activity in tumor cells and its cross-reaction with anti-pigeon liver malic enzyme serum.Mol Cell Biochem. 1988 Feb;79(2):171-9. doi: 10.1007/BF02424560. Mol Cell Biochem. 1988. PMID: 3398839
-
Downregulation of malic enzyme 3 facilitates progression of gastric carcinoma via regulating intracellular oxidative stress and hypoxia-inducible factor-1α stabilization.Cell Mol Life Sci. 2024 Aug 30;81(1):375. doi: 10.1007/s00018-024-05388-9. Cell Mol Life Sci. 2024. PMID: 39212717 Free PMC article.
-
Alternative fuels for cancer cells.Cancer J. 2015 Mar-Apr;21(2):49-55. doi: 10.1097/PPO.0000000000000104. Cancer J. 2015. PMID: 25815843 Free PMC article. Review.
References
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources