A theoretical examination of ionic interactions between neural and non-neural membranes

Abstract

Evidence from electron microscopy indicates that the separation between adjacent membranes of the central nervous system (CNS) is less than 500 A and perhaps as small as 100-250 A. The rapid K(+) efflux associated with the neural action potential may therefore be sufficient to affect the local extracellular potassium concentration and, via their partial dependence upon the potassium equilibrium potential, alter the electrical states of nearby neural and glial membranes. This new concept of a transient and local depolarizing "ionic interaction" between active and inactive membranes of the CNS is here examined theoretically and its magnitude calculated as a function of (a) the intermembrane separation, (b) the membranes' electrochemical characteristics, and (c) the rate at which K(+) can diffuse away from the vicinity of the active (neural) membrane. My results indicate that the interaction is in the millivolt range and therefore significant in the modulation of postsynaptic and presynaptic information processing; in particular configurations the postulated interaction alone may be suprathreshold. Membrane noise and local synchrony in groups of neurons may reflect these local, K(+)-mediated interactions. The transient ionic interaction between active neural and nearby glial membrane is also in the millivolt range; however, the relevance of neuroglia to neuronal function is obscure. Certain pathological states, such as seizure and spreading depression, have an obvious phenomenological correspondence to the results presented here and are briefly discussed.